The aims of the study were to examine the correlation and prediction of different dimensions of vocabulary depth knowledge to academic reading comprehension. Students were instructed to take part in four English-language proficiency tests voluntarily. The research was carried out, administering four instruments, word associates test, morphological knowledge test, and analytic relations test to measure the depth of vocabulary knowledge. In addition, a reading comprehension test that consisted of three reading passages by Longman Test of English as a Foreign Language was adopted and administered for the current study. The results highlighted that the analytic (part–whole) relations, which represented the depth of vocabulary knowledge had the highest correlation with academic reading comprehension in comparison with morphological knowledge and combined syntagmatic and paradigmatic relations, which represented word associates test. Of all the three independent variables, analytical relations made the most statistically significant unique contribution to the prediction of the outcome variable compared to word associates test and morphological knowledge. The present study suggests that the depth of vocabulary knowledge would have practical use for students and English teachers at tertiary level and further implications for lexical researchers.